GMP-TL778 Anti-Human CD137 mAb Induces T cell proliferation thiab cytokine secretion

4-1BB, tseem hu ua CD137, yog ib qho inducible cell nto receptor thiab ib tug tswv cuab ntawm qog necrosis factor receptor (cov qog necrosis factor receptor, TNFR) superfamily. CD137 yog encoded los ntawm cov qog necrosis factor receptor superfamily tus tswv cuab 9 (TNFRSF9) noob thiab nthuav dav rau ntawm qhov chaw ntawm lub tshuab ua kom T cells thiab NK hlwb. Nws ligand, CD137L, kuj yog ib tug tswv cuab TNFSF, yog inducible costimulatory receptor qhia los ntawm activated CD4 + thiab CD8 + T hlwb, NKT, NK hlwb, DC, macrophages, eosinophils, neutrophils thiab mast hlwb, tshwj xeeb tshaj yog nyob rau hauv CD8 + T hlwb. CD137 / CD137L kho cov tshuaj tiv thaiv kab mob los ntawm kev xa cov kev ua kom muaj zog, kev loj hlob, los yog apoptotic signals ntawm lub cev tiv thaiv kab mob. Kev ua kom CD137 tuaj yeem txhawb nqa NK cell thiab T cell proliferation thiab tsim kom muaj kev tiv thaiv qog nqaij hlav, uas ua rau cov lus teb ruaj khov. 4-1BB mAb tuaj yeem qhib 4-1BB los nrhiav TNFR ntsig txog yam TRAF1 thiab TRAF2. Tom qab ntawd, TRAF1 thiab TRAF2 tsim ib qho heterotrimer, uas ntxiv dag zog rau cov teeb liab kis tau los ntawm c-Jun N davhlau ya nyob twg kinase (JNK) lossis extracellular signal-regulated kinase (ERK) txoj hauv kev. Qhov no heterotrimer tuaj yeem txhawb kev loj hlob ntawm T hlwb thiab cov tshuaj tiv thaiv kab mob, txhim kho cov qog nqaij hlav tiv thaiv kab mob hauv lub cev thiab tso cov cytokines los ntawm kev sau ntawm NF-κB.