GMP-TL502 Anti-Human CD52 mAb T cell activation ndi kukula

CD52 ndi antigen yofalitsidwa kwambiri ya GPI anchored glycoprotein yokhala ndi zotsalira khumi ndi ziwiri za amino acid (GQNDTSQTSSPS). CD52 angapezeke padziko lymphocytes, monocytes, eosophils ndi maselo dendritic mu hematopoietic dongosolo. ndi kachulukidwe mpaka 5 × 10⁵molecules pa ma lymphocyte, ma antigen a CD52 amawonetsa zilonda zambiri zama cell a lymphoid ndi ma cell ena oopsa a myeloid leukemia. Mamolekyu a CD52 akalumikizidwa ndi mAb, zimayambitsa ma signature angapo m'maselo omwe mukufuna. Kuzindikiritsa komwe kumachitika chifukwa cha kutsegulira kwa mamolekyu a CD52 ndikofanana ndi komwe kumayambitsidwa ndi ma anti-CD3 antibodies. Ma CD52 ma molekyulu akayambika, PMA (Phorbol Myristate acetate, acetylmyridrobol ester) imatha kulimbikitsa kuchulukira ndi kutulutsa kwa ma cytokines mu CD4⁺ ndi CD8⁺Tlymphocytes mu vitro.