Kukhazikitsa Kwatsopano | Nanoscale Kusankha Mikanda Yamaginito Yolemera Kwambiri~

Gwero: T&L Biotechnology yotulutsidwa nthawi: 2023-09-28

Chithandizo cha Ma cell yakhala ikukula mofulumira m'zaka zaposachedwa mu kafukufuku wamankhwala ndi chitukuko, ndipo ndi njira yatsopano yopangira mankhwala yomwe yasonyeza kuthekera kwakukulu pochiza matenda monga khansa, matenda opatsirana, ndi matenda a autoimmune. Pa Juni 30 chaka chino, National Medical Products Administration (NMPA) yaku China idavomereza kukhazikitsidwa kwa Equecabtagene Autoleucel jekeseni, yopangidwa molumikizana ndi Nanjing Reindeer Biotechnology ndi Innovent Biologics, Inc, yochizira odwala achikulire omwe ali ndi myeloma yobwereza/refractory, idakhala woyamba kuvomerezedwa ndi T CAR therapy ku CAR ndi China-mankhwala ovomerezeka a T CAR Injection ya Axicabtagene Ciloleucel and Relmacabtagene Autoleucel Injection.

Chiyambireni chida choyamba cha CAR-T padziko lonse lapansi kuvomerezedwa kuti chikhazikitsidwe mu 2017, msika wapadziko lonse lapansi wama cell therapy wakula kwambiri, ukuwonjezeka kuchoka pa $ 10 miliyoni mu 2017 mpaka pafupifupi $ 2.7 biliyoni mu 2022. Malinga ndi zomwe Frost & Sullivan adaneneratu, msika wapadziko lonse wa CAR-T cell therapy msika udzafika pa $ 21.48 biliyoni, ndi kukula kwapachaka kwa 21.48 %. 2021 mpaka 2030. Mpaka pano, mankhwala 9 a CAR-T akhazikitsidwa padziko lonse lapansi, ndipo chithandizo cha CAR-T chawala ndi zotsatira zake zabwino kwambiri zochizira zotupa zosiyanasiyana zowopsa. Komabe, chifukwa cha zinthu zosiyanasiyana monga mtengo, kafukufuku ndi chitukuko, kupanga, ndi mphamvu, zinthu za CAR-T nthawi zambiri zimagulidwa pamtengo wa yuan miliyoni imodzi, ndipo mitengo yamtengo wapatali imalepheretsa kugwiritsa ntchito kwawo, zomwe zimapangitsa kuti odwala asapezeke bwino.

Mtengo wokwera wa zinthu za CAR-T umagwirizana kwambiri ndi mtengo wawo wopangira, wokhala ndi ma reagents, zogwiritsidwa ntchito, komanso kutsika kwamitengo yokhazikika yomwe imapanga ndalama zazikulu. Ndi kukulitsidwa kwa sikelo yopangira, mtengo wazinthu zokhazikika umachepetsedwa pang'onopang'ono, ndipo gawo la reagent ndi zogula likupitilira kukwera. Pakadali pano, zida zazikuluzikulu zakhala zikuyendetsedwa ndi mabizinesi akunja, zomwe zimadzetsa mavuto monga nthawi yayitali yoperekera komanso kukwera mtengo, zomwe zikuwopseza mwachindunji chitukuko chachangu chamakampani azachipatala am'nyumba. Chifukwa chake, kuchepetsa mtengo, kukonza bwino, ndi kulowetsa m'malo m'nyumba zakhala nkhani zofala kwambiri m'makampani.
Kukhazikitsa kwatsopano kwa NanoSep™ mndandanda wa nanoscale cell kusanja Magnetic Beads
T&L yakhala ikuyang'ana kwambiri pakufufuza ndi kupanga zida zopangira ma cell ndi gene therapy (CGT) kwazaka zopitilira khumi, ndipo yakhazikitsa NanoSep motsindika kwambiri ™ Series ya ma cell kusanja mikanda yamaginito, yokhala ndi kukula kwa 50nm ndi magwiridwe antchito ofanana ndi omwe amatumizidwa kunja, angagwiritsidwe ntchito popititsa patsogolo makasitomala a T cell kapena kuchotsa makasitomala akunyumba ndikuwongolera mwayi wopambana.

Zogulitsa
Kukula kwa 50nm / chitetezo chachikulu, kukhazikika kwachilengedwe / kukhazikika kwakukulu komanso kusanja bwino kwa ma cell omwe mukufuna / kungapereke mulingo wa RUO ndi GMP mulingo / malo

Zochita zamalonda

Zambiri Zamalonda

Za T&L
T&L Biotechnology Ltd., yomwe idakhazikitsidwa mchaka cha 2011, imayang'ana kwambiri kafukufuku ndi chitukuko cha zida za GMP zopangira ma cell and gene therapy (CGT). Timadzipereka kupereka zinthu zodalirika ndi ntchito za sayansi ya moyo