Recombinant Human GM-CSF mapuloteni

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Chithunzi cha GMP-TL302

Lumikizanani nafe

Kufotokozera

Ziwerengero za Data

Makhalidwe

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Zowonetsa Zamalonda

Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) ndi cytokine yofunika kwambiri yomwe imagwira ntchito yofunika kwambiri pakuwongolera hematopoiesis ndi mayankho a chitetezo chamthupi. GM-CSF imalimbikitsa kusiyanitsa, kufalikira, ndi kuyambitsa ma cell a granulocyte ndi macrophage precursor cell, kupititsa patsogolo ntchito zawo. Puloteni iyi ndiyofunikira pakufufuza kwa immunology, hematology, ndi chithandizo cha khansa.

Zofunika Kwambiri

1.Kuyera Kwambiri: Kuyeretsedwa pogwiritsa ntchito njira zapamwamba za chromatographic, mankhwalawa amakwaniritsa mulingo wachiyero wopitilira 95%, kuwonetsetsa kudalirika kwakukulu ndi kubwerezanso kwa zotsatira zoyesera.

2.High Biological Activity: Kutsimikiziridwa kudzera muzitsulo zambiri za ntchito, puloteni iyi ya GM-CSF imalimbikitsa bwino maselo omwe amawunikira, kuthandizira ntchito zosiyanasiyana zofufuza zokhudzana ndi chitetezo cha mthupi ndi hematopoiesis.

3.Batch Consistency: Zopangidwa ndi njira zoyendetsera khalidwe labwino kwambiri kuti zitsimikizire kusasinthasintha pakati pa magulu, kuchepetsa kusinthasintha ndi kupititsa patsogolo kudalirika kwa zotsatira za kafukufuku.

4.Zopanda Zinyama: Zopangidwa popanda zigawo zochokera ku zinyama, zogwirizana ndi miyezo yopanda zinyama komanso kukulitsa kugwiritsidwa ntchito kwake pazinthu zosiyanasiyana zofufuza.

Mapulogalamu

• Hematology: Phunzirani ntchito ya GM-CSF poyang'anira kupanga maselo a magazi, kuphatikizapo granulocytes ndi macrophages, kupereka zidziwitso za matenda a hematopoietic ndi mankhwala.

• Immunology: Fufuzani zotsatira za GM-CSF pakukula kwa maselo a chitetezo cha mthupi ndi kuthandizira, zomwe zimathandiza kumvetsetsa mozama za mayankho a chitetezo cha mthupi komanso ntchito zochiritsira zomwe zingatheke.

• Kafukufuku wa Khansa: Fufuzani ntchito ya GM-CSF mu microenvironments zotupa ndi zotsatira zake pa chitetezo cha chitetezo cha mthupi, kupereka zidziwitso za immunotherapy ndi njira zothandizira khansa.

• Cell Therapy: Gwiritsani ntchito GM-CSF kuti mupititse patsogolo ntchito ndi kufalikira kwa maselo a chitetezo cha mthupi m'maselo opangidwa ndi maselo, kupititsa patsogolo kafukufuku wamankhwala obwezeretsa ndi immunotherapy.

Tsatanetsatane ndi Kuyika

• Zofotokozera: Zopezeka mumitundu yosiyanasiyana kuti zigwirizane ndi zofunikira zosiyana zoyesera, kuphatikizapo 10μg, 50μg, 100μg, ndi 1mg.

• Kupaka: Amaperekedwa mu mawonekedwe a lyophilized kuti atsimikizire kukhazikika ndikuthandizira kusungirako ndi mayendedwe osavuta.

Kusungirako ndi Kukhazikika

• Kusungirako: Sungani pa -20 ° C kapena pansi kuti mukhalebe ndi mapuloteni okhazikika komanso zochitika zamoyo. Pewani kuzizira kobwerezabwereza kuti mupewe kuwonongeka.

• Kukhazikika: Kumakhalabe kokhazikika kwa kusungidwa kwa nthawi yayitali pansi pamikhalidwe yovomerezeka, kuonetsetsa kuti ntchito yodalirika ikugwira ntchito muzofukufuku.

Malangizo Ogwiritsa Ntchito

1.Sungani ufa wa lyophilized mu malo oyenera osabala m'malo osabala musanagwiritse ntchito.

2.Konzani ndikuchepetsani yankho molingana ndi zofunikira zoyeserera kuti mukwaniritse zolondola komanso zobwereketsa.

3.Pewani kusakanikirana ndi zinthu zina zofananira kuti mupewe kuwoloka komanso kusokoneza komwe kungachitike.

Chenjezo

• Izi zimapangidwira kuti zigwiritsidwe ntchito pofufuza zokha ndipo sizoyenera kuwunikira matenda kapena chithandizo chamankhwala.

• Gwirani mankhwala molingana ndi malangizo omwe aperekedwa kuti mukhale ndi mapuloteni komanso kukhulupirika.

• Pazovuta zilizonse kapena mafunso okhudzana ndi malonda, chonde lemberani gulu lathu laukadaulo.

Ma cytokines
Expression Host	HEK293 maselo
Mawu ofanana	GM-CSF,CSF2,MGC131935
Kutsatizana kwa Mapuloteni	NP_000749.2:A18-E144 idawonetsedwa ndi chizindikiro Chake pa C-terminus.
Misa ya Molecular	Imaneneratu kuchuluka kwa mamolekyu a 15.3kD.
Kuyesedwa kwa QC Kuyera	> 90 % malinga ndi SDS-PAGE.
Endotoxin
Zochita	Kuyesedwa ndi kukondoweza kumadalira mlingo wa kuchuluka kwa maselo a TF-1, ntchito yeniyeni ndi ≥5.0 × 10⁶IU/mg.
Kupanga	Lyophilized kuchokera wosabala PBS, pH 7.4. Nthawi zambiri 6 % mannitol amawonjezedwa ngati chitetezo pamaso lyophilization.
Kukhazikika	Kukonzekera kwa Lyophilized kumatha kusungidwa pa -20 ℃. Miyezi 6 pa -20 ℃ pansi pazikhalidwe zosabala pambuyo pa kukhazikitsidwanso. Miyezi 12 pa -80 ℃ pansi pazikhalidwe zosabala pambuyo pa kukhazikitsidwanso.
Kusungirako	Ndibwino kuti aliquot mapuloteni muchuluke kakang'ono mutatha kukonzanso ndi madzi a jekeseni, saline wamba kapena PBS, ndikusunga ndende yosungunuka pamwamba pa 100μg/mL. Pewani kuzizira kobwerezabwereza.