GMP-TL502 Anti-Human CD52 mAb T cell activation ma le faʻalauteleina

O le CD52 o se antigen fa'asalalau lautele o lo'o iai i le GPI taulala glycoprotein ma na'o le sefululua amino acid toega (GQNDTSQTSSPS). E mafai ona maua le CD52 i luga o le lymphocytes, monocytes, eosophils ma dendritic cell i le hematopoietic system. faʻatasi ai ma le mamafa e oʻo atu i le 5 × 10⁵molecules i luga o lymphocytes, CD52 antigens e faʻaalia i luga o le tele o le lymphoid cell malignancies ma nisi sela leukemia acute myeloid. Pe a fesoʻotaʻi mole CD52 ma le mAb, e faʻaosoina se faasologa o faʻailoga i totonu o sela taulaʻi. O le faʻailoga e mafua mai i le faʻagaoioia o molelaʻau CD52 e tutusa ma le mea e mafua mai i anti-CD3 antibodies. Pe a faʻaosoina molemu CD52, PMA (Phorbol Myristate acetate, acetylmyridrobol ester) e mafai ona faʻalauteleina le faʻateleina ma le faʻamalo o cytokines i le CD4⁺ma CD8⁺Tlymphocytes masani a le tagata i vitro.