GMP-TL778 Anti-Human CD137 mAb fa'aosoina le fa'atuputeleina o le sela T ma le fa'asaoina o le cytokine.

4-1BB, fa'aigoaina fo'i o le CD137, ose fa'ato'a fa'aosoina i luga ole sela ma tasi le sui ole tumo necrosis factor receptor (tumor necrosis factor receptor, TNFR) superfamily. O le CD137 o lo'o fa'ailogaina e le tumo necrosis factor receptor superfamily member 9 (TNFRSF9) gene ma fa'aalia lautele i luga o sela T fa'agaoioia ma sela NK. O lona ligand, CD137L, o se sui TNFSF foi, o se inducible costimulatory receptor faʻaalia e le CD4 + ma CD8 + T faʻagaoioia, NKT, sela NK, DC, macrophages, eosinophils, neutrophils ma sela mast, aemaise lava i luga o CD8 + T sela. O le CD137 / CD137L e fa'afeso'ota'i tali puipuia e ala i le tu'uina atu o le fa'agaoioia, fa'ateleina, po'o fa'ailo apoptotic i le va o sela puipuia. O le faʻagaoioia o le CD137 e mafai ona faʻaosofia ai le NK cell ma le T cell proliferation ma faʻatupuina ai le anti-tumour activity, lea e faʻaosofia ai tali manatua tumau. 4-1BB mAb e mafai ona fa'agaoioia le 4-1BB e fa'aulu ai mea e feso'ota'i TNFR TRAF1 ma TRAF2. Ona, TRAF1 ma TRAF2 fausia se heterotrimer, lea e faʻamalosia ai le faʻaliliuina o faailo e ala i le c-Jun N terminal kinase (JNK) poʻo le extracellular signal-regulated kinase (ERK) ala. O lenei heterotrimer e mafai ona faʻaosofia ai le faʻateleina o sela T ma sela e tuʻuina atu ai le antigen, faʻaleleia le tali atu o le tino ma faʻamalo cytokines e ala i le faʻaliliuga o le NF-κB.